Therapy-Related Transcriptional Subtypes in Matched Primary and Recurrent Head and Neck Cancer.
Peter WeberAxel KünstnerJulia HessKristian UngerSebastian MarschnerChristian IdelChristian IdelPhilipp BaumeisterOlivier GiresChristoph WalzSibylle RietzlerLaura ValeanuTimm HerkommerLisa KreutzerOlena KlymenkoGuido DrexlerThomas KirchnerCornelius MaihöferUte GanswindtAxel WalchMichael SterrHeiko LickertMartin CanisDirk RadesSven PernerMauricio Berriel DiazStefan HerzigKirsten LauberBarbara WollenbergHauke BuschClaus BelkaHorst ZitzelsbergerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Our study showed a high degree of genetic and transcriptional heterogeneity between primary/recurrent tumors, suggesting therapy-related selection of a transcriptional subtype with characteristics unfavorable for therapy. We conclude that therapy decisions should be based on genetic and transcriptional characteristics of recurrences rather than primary tumors to enable optimally tailored treatment strategies.