C5aR1 signaling promotes region- and age-dependent synaptic pruning in models of Alzheimer's disease.
Angela Gomez-ArboledasMaria I FonsecaEnikö KramarShu-Hui ChuNicole D SchartzPurnika SelvanMarcelo A WoodAndrea J TennerPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
C5aR1 ablation restores long-term potentiation in the Arctic model of AD. C5aR1 ablation rescues region specific excessive pre-synaptic loss. C5aR1 antagonist, PMX205, rescues VGlut1 loss in the Tg2576 model of AD. C1q tagging is not sufficient to induce VGlut1 microglial ingestion. Astrocytes contribute to excessive pre-synaptic loss at late stages of the disease.