A review of recent advances in magnetic nanoparticle-based theranostics of glioblastoma.
Dhruba DharSwachhatoa GhoshSoumen DasJyotirmoy ChatterjeePublished in: Nanomedicine (London, England) (2022)
Rapid vascular growth, infiltrative cells and high tumor heterogenicity are some glioblastoma multiforme (GBM) characteristics, making it the most lethal form of brain cancer. Low efficacy of the conventional treatment modalities leads to rampant disease progression and a median survival of 15 months. Magnetic nanoparticles (MNPs), due to their unique physical features/inherent abilities, have emerged as a suitable theranostic platform for targeted GBM treatment. Thus, new strategies are being designed to enhance the efficiency of existing therapeutic techniques such as chemotherapy, radiotherapy, and so on, using MNPs. Herein, the limitations of the current therapeutic strategies, the role of MNPs in mitigating those inadequacies, recent advances in the MNP-based theranostics of GBM and possible future directions are discussed.
Keyphrases
- magnetic nanoparticles
- induced apoptosis
- locally advanced
- early stage
- physical activity
- mental health
- photodynamic therapy
- oxidative stress
- resting state
- cell cycle arrest
- squamous cell carcinoma
- high resolution
- signaling pathway
- drug delivery
- functional connectivity
- radiation induced
- white matter
- mass spectrometry
- blood brain barrier
- molecularly imprinted
- fluorescence imaging
- pi k akt
- lymph node metastasis