Genome-wide association study on Northern Chinese identifies KLF2, DOT1L and STAB2 associated with systemic lupus erythematosus.
Qin SongYao LeiLi ShaoWeiyang LiQingsheng KongZhiming LinXiao QinWei WeiFei HouJian LiXianghua GuoYujing MaoYujie CaoZhongyi LiuLichuan ZhengRui LiangYuping JiangYan LiuLili ZhangJing YangYu Lung LauYan ZhangBo BanYong-Fei WangWanling YangPublished in: Rheumatology (Oxford, England) (2021)
We identified three loci associated with SLE, with KLF2 a likely Chinese-specific locus, highlighting the importance of studying diverse populations in SLE genetics. We hypothesize that DOT1L and KLF2 are plausible SLE treatment targets, with inhibitors of DOT1L and inducers of KLF2 already available clinically.