Type I IFN signaling limits hemorrhage-like disease after infection with Japanese encephalitis virus through modulating a prerequisite infection of CD11b+Ly-6C+ monocytes.

Ajit Mahadev PatilJin Young ChoiSeong Ok ParkErdenebelig UyangaaBumseok KimKoanhoi KimSeong Kug Eo

Published in: Journal of neuroinflammation (2021)

An IFN-I signal-dependent model is proposed to demonstrate how CD11b+Ly-6C+ monocytes are involved in restricting the tissue tropism of JEV to the CNS.

Keyphrases

dendritic cells
immune response
peripheral blood
nk cells
blood brain barrier
signaling pathway