Claudin-6 increases SNAI1, NANOG and SOX2 gene expression in human gastric adenocarcinoma AGS cells.
Priscila Anhel Medrano-GonzálezlFranklin Cruz-VillegasAlejandro Alarcón Del CarmenLuis Felipe MontañoErika Patricia Rendón-HuertaPublished in: Molecular biology reports (2022)
The pro-tumorigenic effect of claudin-6 in gastric cancer could be associated to dedifferentiation of epithelial cells and an increase in di novo cancer stem cell genesis.
Keyphrases
- cancer stem cells
- gene expression
- induced apoptosis
- endothelial cells
- cell cycle arrest
- stem cells
- dna methylation
- squamous cell carcinoma
- induced pluripotent stem cells
- anti inflammatory
- endoplasmic reticulum stress
- locally advanced
- biofilm formation
- signaling pathway
- oxidative stress
- cell proliferation
- radiation therapy