Towards robust and replicable sex differences in the intrinsic brain function of autism.

Dorothea L Floris José O A Filho Meng-Chuan LaiSteve GiavasisMarianne OldehinkelMaarten Mennes Tony Charman Julian Tillmann Guillaume DumasChristine EckerFlavio Dell'Acqua Tobias Banaschewski Carolin Moessnang Simon Baron-CohenSarah DurstonEva LothDeclan G M Murphy Jan K Buitelaar Christian F Beckmann Michael Peter Milham Adriana Di Martino

Published in: Molecular autism (2021)

Atypical cross-hemispheric interactions are neurobiologically relevant to autism. They likely result from the combination of sex-dependent and sex-independent factors with a differential effect across functional cortical networks. Systematic assessments of the factors contributing to replicability are needed and necessitate coordinated large-scale data collection across studies.

Keyphrases

autism spectrum disorder
intellectual disability
electronic health record
resting state
big data
functional connectivity
case control
brain injury
artificial intelligence