Peripheral mitochondrial DNA, telomere length and DNA methylation as predictors of live birth in in vitro fertilization cycles.

Letizia Li PianiMarco ReschiniEdgardo SomiglianaStefania FerrariAndrea BusnelliPaola ViganòChiara FaveroBenedetta AlbettiMirjam HoxhaValentina Bollati

Published in: PloS one (2022)

DNAm age is associated with IVF success but the magnitude of this association is insufficient to claim a clinical use. However, our findings are promising and warrant further investigation. Assessment of biological age using different epigenetic clocks or focusing on different tissues may reveal new predictors of IVF success.

Keyphrases

mitochondrial dna
dna methylation
copy number
genome wide
gene expression
pregnancy outcomes
single cell
pregnant women