Sex differences in chest electrical impedance tomography findings.

Objective. Electrical impedance tomography (EIT) has been used to determine regional lung ventilation distribution in humans for decades, however, the effect of biological sex on the findings has hardly ever been examined. The aim of our study was to determine if the spatial distribution of ventilation assessed by EIT during quiet breathing was influenced by biological sex. Approach. 219 adults with no known acute or chronic lung disease were examined in sitting position with the EIT electrodes placed around the lower chest (6th intercostal space). EIT data were recorded at 33 images/s during quiet breathing for 60 s. Regional tidal impedance variation was calculated in all EIT image pixels and the spatial distribution of the values was determined using the established EIT measures of centre of ventilation in ventrodorsal (CoV vd ) and right-to-left direction (CoV rl ), the dorsal and right fraction of ventilation, and ventilation defect score. Main results. After exclusion of one subject due to insufficient electrode contact, 218 data sets were analysed (120 men, 98 women) (age: 53 ± 18 vs 50 ± 16 yr ( p = 0.2607), body mass index: 26.4 ± 4.0 vs 26.4 ± 6.6 kg m -2 ( p = 0.9158), mean ± SD). Highly significant differences in ventilation distribution were identified between men and women between the right and left chest sides (CoV rl : 47.0 ± 2.9 vs 48.8 ± 3.3% of chest diameter ( p < 0.0001), right fraction of ventilation: 0.573 ± 0.067 vs 0.539 ± 0.071 ( p = 0.0004)) and less significant in the ventrodorsal direction (CoV vd : 55.6 ± 4.2 vs 54.5 ± 3.6% of chest diameter ( p = 0.0364), dorsal fraction of ventilation: 0.650 ± 0.121 vs 0.625 ± 0.104 ( p = 0.1155)). Ventilation defect score higher than one was found in 42.5% of men but only in 16.6% of women. Significance. Biological sex needs to be considered when EIT findings acquired in upright subjects in a rather caudal examination plane are interpreted. Sex differences in chest anatomy and thoracoabdominal mechanics may explain the results.