LRRC8A anion channels modulate vasodilation via association with Myosin Phosphatase Rho Interacting Protein (MPRIP).
Hyehun ChoiMichael R MillerHong-Ngan NguyenJeffrey C RohrboughStephen R KochNaoko BoatwrightMichael T YarboroRajan SahW Hayes McDonaldJ Jeffrey ReeseRyan J StarkFred S LambPublished in: bioRxiv : the preprint server for biology (2023)
Interaction of Nox1/LRRC8A with MPRIP/RhoA/MYPT1/actin may allow redox regulation of the cytoskeleton and link Nox1 activation to both inflammation and vascular contractility.