LRRC8A anion channels modulate vasodilation via association with Myosin Phosphatase Rho Interacting Protein (MPRIP).

Hyehun ChoiMichael R MillerHong-Ngan NguyenJeffrey C RohrboughStephen R KochNaoko BoatwrightMichael T YarboroRajan SahW Hayes McDonaldJ Jeffrey ReeseRyan J StarkFred S Lamb

Published in: bioRxiv : the preprint server for biology (2023)

Interaction of Nox1/LRRC8A with MPRIP/RhoA/MYPT1/actin may allow redox regulation of the cytoskeleton and link Nox1 activation to both inflammation and vascular contractility.

Keyphrases

protein kinase
binding protein
reactive oxygen species
smooth muscle
oxidative stress
ionic liquid
protein protein
amino acid
small molecule
electron transfer