Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators.
Shiyu ZhangAndrew P HolmesAlexej DickAdel A RashadLucía Enríquez RodríguezGabriela A CanzianiMichael J RootIrwin M ChaikenPublished in: Retrovirology (2021)
Together, the data suggest that the escape mutations significantly modified the energetic landscape of Env's prefusogenic state, altering conformational dynamics to hinder PT-induced irreversible inactivation of Env. This work therein reveals a unique mode of virus escape for HIV-1, namely, resistance by altering the intrinsic conformational dynamics of the Env trimer.
Keyphrases
- antiretroviral therapy
- molecular dynamics
- molecular dynamics simulations
- hiv positive
- single molecule
- hiv infected
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- men who have sex with men
- south africa
- big data
- high glucose
- electronic health record
- diabetic rats
- single cell
- machine learning
- artificial intelligence
- endothelial cells