Extracellular vesicles from deciduous pulp stem cells recover bone loss by regulating telomerase activity in an osteoporosis mouse model.

Soichiro SonodaSara MurataKento NishidaHiroki KatoNorihisa UeharaYukari N KyumotoHaruyoshi YamazaIchiro TakahashiToshio KukitaTakayoshi Yamaza

Published in: Stem cell research & therapy (2020)

Collectively, our findings suggest that SHED-secreted RNAs, such as microRNAs, play a crucial role in treating postmenopausal osteoporosis by targeting the telomerase activity of recipient BMMSCs.

Keyphrases

bone mineral density
bone loss
stem cells
postmenopausal women
mouse model
body composition
mesenchymal stem cells