Opioid presynaptic disinhibition of the midbrain periaqueductal grey descending analgesic pathway.

Benjamin K Lau Bryony L Winters Christopher W Vaughan

Published in: British journal of pharmacology (2020)

These findings suggest that μ-opioids activate the descending analgesic pathway from the midbrain PAG by a combination of presynaptic disinhibition of RVM-projecting neurons and postsynaptic inhibition of presumptive interneurons.

Keyphrases

chronic pain
pain management
neuropathic pain
anti inflammatory
spinal cord
white matter
spinal cord injury
multiple sclerosis