Fructose-1,6-Bisphosphate Aldolase B Depletion Promotes Hepatocellular Carcinogenesis Through Activating Insulin Receptor Signaling and Lipogenesis.
Guijun LiuNingning WangCunzhen ZhangMin LiXuxiao HeChunzhao YinQiaochu TuXia ShenLili ZhangJingwen LvYongqiang WangHuimin JiangShiting ChenNan LiYongzhen TaoHui-Yong YinPublished in: Hepatology (Baltimore, Md.) (2021)
Our study reports a mechanism by which loss of ALDOB activates IR signaling primarily through releasing IR/ALDOB interaction to promote DNL and HCC, highlighting a potential therapeutic strategy in HCC.