Wide-field mid-infrared hyperspectral imaging beyond video rate.
Jianan FangKun HuangRuiyang QinYan LiangE WuMing YanHeping ZengPublished in: Nature communications (2024)
Mid-infrared hyperspectral imaging has become an indispensable tool to spatially resolve chemical information in a wide variety of samples. However, acquiring three-dimensional data cubes is typically time-consuming due to the limited speed of raster scanning or wavelength tuning, which impedes real-time visualization with high spatial definition across broad spectral bands. Here, we devise and implement a high-speed, wide-field mid-infrared hyperspectral imaging system relying on broadband parametric upconversion of high-brightness supercontinuum illumination at the Fourier plane. The upconverted replica is spectrally decomposed by a rapid acousto-optic tunable filter, which records high-definition monochromatic images at a frame rate of 10 kHz based on a megapixel silicon camera. Consequently, the hyperspectral imager allows us to acquire 100 spectral bands over 2600-4085 cm -1 in 10 ms, corresponding to a refreshing rate of 100 Hz. Moreover, the angular dependence of phase matching in the image upconversion is leveraged to realize snapshot operation with spatial multiplexing for multiple spectral channels, which may further boost the spectral imaging rate. The high acquisition rate, wide-field operation, and broadband spectral coverage could open new possibilities for high-throughput characterization of transient processes in material and life sciences.
Keyphrases
- optical coherence tomography
- high speed
- high resolution
- high throughput
- dual energy
- photodynamic therapy
- deep learning
- multiple sclerosis
- atomic force microscopy
- ms ms
- magnetic resonance imaging
- minimally invasive
- mass spectrometry
- computed tomography
- molecular dynamics
- molecular dynamics simulations
- optic nerve
- quantum dots
- machine learning
- light emitting