Alcohol, place conditioning, and male rats: A systematic review for outcome prediction.

We recommend settings for CPP induction in short protocols, indicate the predictive analysis has broad consequences (from theoretical to translational ones) for PC in alcohol research, and specify variables needing more accurate investigation (rat sex, age, weight, strain, spatial configuration of the apparatus, and conditioning timetable). This review may improve our comprehension of results of alcohol-induced PC with rats, refining our understanding of the motivator function of alcohol and the alcohol-seeking behavior triggered by environmental contexts, and opening new research venues on their neurobiological basis.