The effect of liver metastases on clinical efficacy of first-line programmed death-1 inhibitor plus chemotherapy in esophageal squamous cell carcinoma: A post hoc analysis of ASTRUM-007 and meta-analysis.

Jing GaoYan SongXiaoge KouZhenbo TanShu ZhangMeili SunJin ZhouMin FanMing ZhangYongxiang SongSuyi LiYuan YuanWu ZhuangJingdong ZhangLi ZhangHao JiangKangsheng GuHuangyang YeYing KeXiao QiQingyu WangJun ZhuJing Huang

Published in: Cancer medicine (2024)

This study reveals that the presence of liver metastases is a poor prognostic factor but does not affect the improvements in both PFS and OS brought by adding PD-1 blockade to chemotherapy in ESCC patients. Predictive biomarkers for survival in these patients warrant further investigation.

Keyphrases

prognostic factors
liver metastases
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
squamous cell carcinoma
radiation therapy
rectal cancer