New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239.
Satoru ShigenoMiyu KadowakiKenichiro NagaiKanji HosodaTakeshi TeraharaTomoyasu NishimuraNaoki HasegawaHiroshi TomodaTaichi OhshiroPublished in: The Journal of antibiotics (2024)
During our screening for anti-mycobacterial agents against Mycobacterium avium complex (MAC), two new polycyclic tetramate macrolactams (PTMs), named hydroxycapsimycin (1) and brokamycin (2), were isolated along with the known PTM, ikarugamycin (3), from the culture broth of marine-derived Streptomyces sp. KKMA-0239. The relative structures of 1 and 2 were elucidated by spectroscopic data analyses, including 1D and 2D NMR. Furthermore, the absolute configuration of 1 was confirmed by a single-crystal X-ray diffraction analysis. Compounds 2 and 3 exhibited moderate antimycobacterial activities against MAC, including clinically isolated drug-resistant M. avium.
Keyphrases
- drug resistant
- high resolution
- multidrug resistant
- mycobacterium tuberculosis
- acinetobacter baumannii
- magnetic resonance
- molecular docking
- solid state
- high intensity
- big data
- electron microscopy
- magnetic resonance imaging
- machine learning
- computed tomography
- pseudomonas aeruginosa
- artificial intelligence
- crystal structure
- contrast enhanced