Microglia measured by TSPO PET are associated with Alzheimer's disease pathology and mediate key steps in a disease progression model.

Samantha M RossanoAubrey S JohnsonAnna SmithGalen ZiaggiAndrew RoetmanDiana GuzmanAmarachukwu OkaforJulia KleinZeljko TomljanovicYaakov SternAdam M BrickmanSeonjoo LeeWilliam C KreislPatrick J Lao

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Microglia are associated with AD pathology and cognition and may mediate relationships between subsequent steps in AD progression.

Keyphrases

inflammatory response
pet imaging
neuropathic pain
computed tomography
cognitive decline
mild cognitive impairment
positron emission tomography
white matter
multiple sclerosis