Effect of Xuefu Zhuyu Capsule on Myocardial Infarction: Network Pharmacology and Experimental Verification.

Jinlong DuanJianguo LinNixue ZhangQingqing WangNa LiKui-Wu Yao

Published in: Evidence-based complementary and alternative medicine : eCAM (2023)

This study demonstrated that SIRT1 may be the target of XFC in the treatment of MI. The active ingredients of XFC and SIRT1 can be stably bound. XFC could inhibit apoptosis, promote angiogenesis, and improve myocardial fibrosis through SIRT1.

Keyphrases

oxidative stress
ischemia reperfusion injury
left ventricular
heart failure
endothelial cells
endoplasmic reticulum stress
cell death
vascular endothelial growth factor
cell cycle arrest
signaling pathway
wound healing
smoking cessation
pi k akt