Pharmacogenomics of cisplatin-induced neurotoxicities: Hearing loss, tinnitus, and peripheral sensory neuropathy.

Xindi ZhangMatthew R TrendowskiEmma WilkinsonMohammad ShahbaziPaul C DinhMegan M Shueynull nullDarren R FeldmanRobert J HamiltonDavid J VaughnChunkit FungChristian KollmannsbergerRobert HuddartNeil E MartinVictoria A SanchezRobert D FrisinaLawrence H EinhornNancy J CoxLois B TravisMary Eileen Dolan

Published in: Cancer medicine (2022)

Genetics variants in TXNRD1 and WNT8A are notable risk factors for hearing loss and tinnitus, respectively. Future studies should investigate these genes and if replicated, identify their potential impact on preventive strategies.

Keyphrases

hearing loss
stem cells
genome wide
cell proliferation
copy number
current status
case control
adverse drug
emergency department
human health
clinical decision support
risk assessment
gene expression
chemotherapy induced
dna methylation