Glycine Receptor β-Targeting Autoantibodies Contribute to the Pathology of Autoimmune Diseases.
Anna-Lena WiesslerIvan TalucciInken PiroSabine SeefriedVerena HörlinBetül B BaykanErdem TuzunNatascha SchaeferHans M MaricClaudia SommerCarmen VillmannPublished in: Neurology(R) neuroimmunology & neuroinflammation (2024)
Our study establishes GlyRβ as novel target of aAb in patients with SPS/PERM. In contrast to exclusively GlyRα1-positive sera, which alter glycine potency, aAbs against GlyRβ impair receptor efficacy for the neurotransmitter glycine. Imaging and functional analyses showed that GlyRβ aAbs antagonize inhibitory neurotransmission by affecting receptor function rather than localization.