Activity and Resistance of a Brain-Permeable Paradox Breaker BRAF Inhibitor in Melanoma Brain Metastasis.
Ester Bonfill-TeixidorRaffaella IurlaroCornelia HandlJürgen WichmannAlexandra AriasIsabel CuartasJasmin EmmeneggerAndrea RomagnaniLuca ManganoThomas LorberMarco BerreraChristina Godfried SieFabian KöchlJan EckmannRomi FeddersenMartin KornackerGabriel SchnetzlerMarta CicuéndezEsteban CorderoThomaz E TopczewskiAbel Ferres-PijoanJosep GonzálezFrancisco Martínez-RicarteEva Muñoz CouseloJosep TaberneroJames R BischoffPiergiorgio PettazzoniJoan SeoanePublished in: Cancer research (2022)
A brain-penetrant BRAF inhibitor demonstrates potent activity in brain metastatic melanoma, even upon relapse following standard BRAF inhibitor therapy, supporting further investigation into its clinical utility.