The utility of DNA methylation profiling in the diagnosis of un-, de- and trans-differentiated melanoma: a series of 11 cases.
Zeynep Betul ErdemBaptiste AmelineJudith V M G BovéeHester van BovenDaniel BaumhoerJohn S A ChrisingerKaren J FritchiePublished in: Histopathology (2024)
Despite loss of differentiation and phenotypical plasticity, methylation patterns seem to be retained in undifferentiated, de-differentiated and trans-differentiated melanomas and represent useful diagnostic tools to enhance diagnostic precision in these diagnostically challenging cases.