Levels of Cytokines and MicroRNAs in Individuals With Asymptomatic Hyperuricemia and Ultrasonographic Findings of Gout: A Bench-to-Bedside Approach.

Irving O Estevez-GarciaSelma Gallegos-NavaErika Vera-PérezLuis H SilveiraLucio Ventura-RíosGonzalo VanciniCristina Hernández-DíazFausto Sánchez-MuñozMartha A Ballinas-VerdugoMarwin GutierrezCarlos PinedaPedro Rodriguez-HenriquezDiana Castillo-MartínezLuis M Amezcua Guerra

Published in: Arthritis care & research (2018)

In individuals with chronic asymptomatic hyperuricemia, the presence of synovitis and double contour sign by US may represent a subclinical manifestation of monosodium urate crystal nucleation, capable of triggering inflammatory pathways (IL-6 and IL-8) and mechanisms of intercellular communication (miR-155), similar to what is observed in patients with gout.

Keyphrases

uric acid
metabolic syndrome
cell proliferation
long non coding rna
oxidative stress
long noncoding rna
optic nerve