Dapagliflozin Attenuates Na+/H+ Exchanger-1 in Cardiofibroblasts via AMPK Activation.

Yumei YeXiaoming JiaMandeep BajajYochai Birnbaum

Published in: Cardiovascular drugs and therapy (2019)

Dapa increases P-AMPK in cardiofibroblasts exposed to LPS. Dapa attenuated the increase in NHE-1 mRNA and the association between NHE-1 and Hsp70. This effect was dependent on AMPK.

Keyphrases

skeletal muscle
protein kinase
inflammatory response
heat stress
anti inflammatory
heat shock
binding protein