Comparative Genomic Analysis and Clinical Outcomes of BRAF-mutated Advanced Biliary Tract Cancers.
Tin-Yun TangFederico NichettiBenjamin KaplanSara LonardiFilippo PietrantonioLisa SalvatoreCaterina VivaldiLorenza RimassaFilippo G De BraudMario Domenico RizzatoDean C PavlickRandy ChuAnaemy Danner De ArmasRadwa SharafEthan S SokolJordi Rodon AhnertJeffery S RossMilind M JavleMonica NigerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
In BTC, all classes of BRAF mutations are associated with a worse prognosis. BRAF mutations occur in 5% of iCCA subgroup and may be mutually exclusive with other targetable mutations.