Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells.
Jiancheng WangXin LiuYuan QiuYue ShiJianye CaiBoyan WangXiaoyue WeiQiong KeXin SuiYi WangYinong HuangHongyu LiTao WangRen LinQifa LiuAndy Peng XiangPublished in: Journal of hematology & oncology (2018)
We show evidence that mitochondria transfer from Jurkat cells to MSCs, which is mediated by cell adhesion, may be a potential therapeutic target for T-ALL treatment.
Keyphrases
- cell adhesion
- induced apoptosis
- acute lymphoblastic leukemia
- cell cycle arrest
- mesenchymal stem cells
- cell death
- bone marrow
- signaling pathway
- endoplasmic reticulum stress
- oxidative stress
- stem cells
- cell proliferation
- endoplasmic reticulum
- acute myeloid leukemia
- diabetic rats
- drug induced
- pi k akt
- climate change
- cell therapy
- replacement therapy
- stress induced