Methotrexate Ameliorates Systemic Inflammation and Septic Associated-Lung Damage in a Cecal Ligation and Puncture Septic Rat Model.

Josep Bringué Raquel Guillamat-Prats Maria Luisa MartinezEva TorrentsMarta Camprubí-RimblasLluís BlanchAntonio Artigas

Published in: International journal of molecular sciences (2021)

A single, low dose of MTX attenuates sepsis lung-associated damage by decreasing pro-inflammatory response, infiltration of pro-inflammatory cells and avoiding defective tissue lung remodeling.

Keyphrases

low dose
acute kidney injury
inflammatory response
oxidative stress
high dose
induced apoptosis
intensive care unit
lipopolysaccharide induced
mouse model
anti inflammatory
ultrasound guided