Population pharmacodynamic modelling of midazolam induced sedation in terminally ill adult patients.

Linda G W FrankenBrenda C M de WinterAnniek D MasmanMonique van DijkFrans P M BaarDick TibboelBirgit C P KochTeun van GelderRon A A Mathot

Published in: British journal of clinical pharmacology (2017)

We were able to describe the clinical response to midazolam accurately. As expected, there was large variability in response to midazolam. The use of haloperidol was associated with a lower probability of sedation. This may be a result of confounding by indication, as haloperidol was used to treat delirium, and deliria has been linked to a more difficult sedation procedure.

Keyphrases

mechanical ventilation
high glucose
cardiac surgery
diabetic rats
minimally invasive
drug induced