Genetic associations of T cell cancer immune response-related genes with T cell phenotypes and clinical outcomes of early-stage lung cancer.
Qinchuan WangJianchun GuLinbo WangDavid W ChangYuanqing YeMaosheng HuangJack A RothXifeng WuPublished in: Journal for immunotherapy of cancer (2021)
Genetic variations in T cell cancer immune response pathways can impact outcomes and may be served as predictors for treatment efficacy in early-stage NSCLC patients. The correlation between immune genotypes and T cell antitumor immunity suggests a biological link between host immune genetics and NSCLC prognosis.
Keyphrases
- early stage
- immune response
- papillary thyroid
- small cell lung cancer
- end stage renal disease
- squamous cell
- chronic kidney disease
- newly diagnosed
- genome wide
- sentinel lymph node
- dendritic cells
- toll like receptor
- copy number
- prognostic factors
- type diabetes
- squamous cell carcinoma
- gene expression
- radiation therapy
- dna methylation
- brain metastases
- lymph node
- insulin resistance
- rectal cancer
- smoking cessation