Role of TLR9 methylation on its active transcription in apical inflammation.

Alejandra FernándezJessica AstorgaMaría José BordagarayMaría Jesús LiraPeter J Gebicke-HaerterMarcela Hernandez

Published in: International endodontic journal (2022)

Demethylations of TLR9 promoter CpG sites, along with the intragenic DNA methylation status, were involved in higher transcription in ALEO. Hence, chronic periapical inflammation and ageing modify the methylation status both in the gene promoter and in intragenic CpG islands.

Keyphrases

dna methylation
genome wide
oxidative stress
toll like receptor
gene expression
copy number
inflammatory response
transcription factor
immune response
nuclear factor
genome wide identification