A unique phenotype of T-cell acute lymphoblastic leukemia in a patient with GATA2 haploinsufficiency.
Orlando EsparzaAna C XavierT Prescott AtkinsonBenjamin C HillKimberly WhelanPublished in: Pediatric blood & cancer (2019)
Germline or acquired mutations involving the GATA-binding protein gene (GATA2) have been linked to a variety of clinical conditions. In addition, patients harboring GATA2 mutations have a striking predisposition to develop myeloid malignancies, such as myelodysplastic syndrome or acute myeloid leukemia, but not acute lymphoblastic leukemia (ALL). We report here a unique occurrence of early T-cell precursor ALL in a young child with GATA2 haploinsufficiency.
Keyphrases
- acute lymphoblastic leukemia
- transcription factor
- acute myeloid leukemia
- allogeneic hematopoietic stem cell transplantation
- binding protein
- end stage renal disease
- ejection fraction
- newly diagnosed
- risk assessment
- bone marrow
- peritoneal dialysis
- dendritic cells
- genome wide
- dna repair
- dna methylation
- middle aged
- dna damage