Effects of human umbilical cord mesenchymal stem cells on inflammatory factors and miR-181a in T lymphocytes from patients with systemic lupus erythematosus.
B ZhengP ZhangL YuanR K ChhetriY GuoDanqi DengPublished in: Lupus (2019)
UC-MSCs have showed certain immunomodulatory and inhibitory effects in vitro on T lymphocytes from SLE patients, which could potentially be a beneficial treatment of the disease. UC-MSCs may up-regulate miR-181a and down-regulate inflammation-related gene expression.
Keyphrases
- mesenchymal stem cells
- umbilical cord
- gene expression
- cell proliferation
- long non coding rna
- bone marrow
- end stage renal disease
- oxidative stress
- long noncoding rna
- endothelial cells
- cell therapy
- systemic lupus erythematosus
- ejection fraction
- newly diagnosed
- chronic kidney disease
- dna methylation
- prognostic factors
- stem cells
- rheumatoid arthritis
- disease activity
- combination therapy
- patient reported outcomes