ABCA1 and ABCG1 DNA methylation in epicardial adipose tissue of patients with coronary artery disease.

Valentina V MiroshnikovaAlexandra A PanteleevaIrina A PobozhevaNatalia D RazgildinaEkaterina A PolyakovaAnton V MarkovOlga D BelyaevaOlga A BerkovichElena I BaranovaMaria S NazarenkoValery P PuzyrevSofya N Pchelina

Published in: BMC cardiovascular disorders (2021)

CAD is associated with ABCA1 and ABCG1 DNA hypermethylation in EAT. CAD with concomitant carotid artery disease or peripheral artery disease is accompanied by decreased ABCA1 gene expression in EAT. DNA methylation levels at the ABCG1 cg27243685 locus in SAT are associated with hypertriglyceridemia and obesity.

Keyphrases

dna methylation
gene expression
peripheral artery disease
adipose tissue
coronary artery disease
insulin resistance
genome wide
cancer stem cells
type diabetes
weight loss
cell free
circulating tumor
high fat diet
single molecule
weight gain
physical activity
genome wide association study
skeletal muscle