NODDI in gray matter is a sensitive marker of aging and early AD changes.

Xi YuScott A PrzybelskiRobert I ReidTimothy G LesnickSheelakumari RaghavanJonathan Graff-RadfordVal J LoweKejal KantarciDavid S KnopmanRonald C PetersenClifford R JackPrashanthi Vemuri

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2024)

Neurite orientation dispersion and density imaging can serve as an effective brain health biomarker for aging and early Alzheimer's disease (AD).Free water fraction has higher sensitivity to normal brain aging.Free water fraction has stronger associations with early AD and regional tau deposition.

Keyphrases

healthcare
public health
white matter
resting state
high resolution
mental health
cognitive decline
multiple sclerosis
cerebral ischemia
mass spectrometry
risk assessment