Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d-galactosamine induced acute liver injury.
Zheng LiHaihua FengLu HanLu DingBingyu ShenYe TianLilei ZhaoMeiyu JinQi WangHaiyan QinJiaqi ChengGuo-Wen LiuPublished in: Journal of cellular and molecular medicine (2020)
Chicoric acid is polyphenol of natural plant and has a variety of bioactivity. Caused by various kinds of stimulating factors, acute liver injury has high fatality rate. The effect of chicoric acid in acute liver injury induced by Lipopolysaccharide (LPS) and d-galactosamine (d-GalN) was investigated in this study. The results showed that CA decreased the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum and reduced the mortality induced by LPS/d-GalN. CA can restrain mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) to alleviate inflammation. Meanwhile, the results indicated CA can active nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway with increasing the level of AMP-activated protein kinase (AMPK). And with the treatment of CA, protein levels of autophagy genes were obvious improved. The results of experiments indicate that CA has protective effect in liver injury, and the activation of AMPK and autophagy may make sense.
Keyphrases
- liver injury
- drug induced
- nuclear factor
- protein kinase
- oxidative stress
- toll like receptor
- inflammatory response
- lps induced
- induced apoptosis
- signaling pathway
- diabetic rats
- liver failure
- dna damage
- type diabetes
- endoplasmic reticulum stress
- ischemia reperfusion injury
- skeletal muscle
- immune response
- anti inflammatory
- cardiovascular disease
- extracorporeal membrane oxygenation
- intensive care unit
- acute respiratory distress syndrome
- amino acid
- atomic force microscopy