Effect of Placenta-Derived Mesenchymal Stem Cells in a Dementia Rat Model via Microglial Mediation: a Comparison between Stem Cell Transplant Methods.

Jae Sung Cho Jihyeon LeeDa Un JeongHan Wool KimWon Seok ChangJisook MoonJin Woo Chang

Published in: Yonsei medical journal (2018)

Our results suggest that ICV and IV injections of pMSCs facilitate the recovery of cholinergic neuronal populations and cognitive behavior. This recovery likely occurs through paracrine effects that resemble microglia function rather than direct differentiation of injected pMSCs into cholinergic neurons.

Keyphrases

stem cells
inflammatory response
neuropathic pain
mild cognitive impairment
spinal cord
lipopolysaccharide induced
lps induced
platelet rich plasma
spinal cord injury
brain injury
mesenchymal stem cells
genetic diversity