Claudin-10a Deficiency Shifts Proximal Tubular Cl - Permeability to Cation Selectivity via Claudin-2 Redistribution.
Tilman BreiderhoffNina HimmerkusLuca MeoliAnja FrommSebastian SewerinNatalia KriuchkovaOliver NagelYury LadilovSusanne M KrugCatarina QuintanovaMeike StumppDieter Garbe-SchönbergUlrike WesternströerCosima MerkelMerle Annette BrinkhusJanine AltmüllerMichal R SchweigerDominik MüllerKerim MutigMarkus MorawskiJan HalbritterSusanne MilatzMarkus BleichDorothee GünzelPublished in: Journal of the American Society of Nephrology : JASN (2022)
Claudin-10a is the major paracellular anion channel in the proximal tubule and its deletion causes calcium and magnesium hyper-reabsorption by claudin-2 redistribution. Transcellular transport in proximal and distal segments and proximal tubular metabolic adaptation compensate for loss of paracellular anion permeability.