Metabolic effects of carvedilol through β-arrestin proteins: investigations in a streptozotocin-induced diabetes rat model and in C2C12 myoblasts.

Berna Güven Zümra Kara Arzu Onay Beşikçi

Published in: British journal of pharmacology (2020)

The metabolic effects of carvedilol seem to be related to biased activation of β-arrestins. Patients with cardiovascular and metabolic disorders may benefit from new compounds that selectively act on β-arrestins.

Keyphrases

diabetic rats
type diabetes
cardiovascular disease
high fat diet
high glucose
oxidative stress
adipose tissue
metabolic syndrome
diabetic nephropathy