Elevated TNF-α Induces Thrombophagocytosis by Mononuclear Cells in ex vivo Whole-Blood Co-Culture with Dengue Virus.

Rahmat Dani SatriaMing-Kai JhanChia-Ling ChenPo-Chun TsengYung-Ting WangChiou-Feng Lin

Published in: Journal of inflammation research (2022)

These results demonstrate the potential pathogenesis of thrombocytopenia caused by TNF-α-induced thrombophagocytosis in monocytes during DENV infection.

Keyphrases

dengue virus
zika virus
rheumatoid arthritis
induced apoptosis
aedes aegypti
peripheral blood
cell cycle arrest
high glucose
endoplasmic reticulum stress
drug induced
cell death
immune response
human health
cell proliferation
risk assessment