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Chromosomal microarray testing yield in 829 cases of microcephaly: a clinical characteristics-based analysis for prenatal and postnatal cases.

Rivka Sukenik-HalevyNir MevorachLina Basel-SalmonReut Tomashov MatarSarit KahanaKochav KleinIfaat Agmon-FishmanMichal LevyIdit Maya
Published in: Archives of gynecology and obstetrics (2024)
The yield of CMA testing in prenatal microcephaly is lower than in postnatal cases (4.6% vs. 15%). The presence of microcephaly, combined with dysmorphism, hypotonia, epilepsy, CHD, LD, and FGR, significantly increases the likelihood of an abnormal CMA result.
Keyphrases
  • zika virus
  • intellectual disability
  • pregnant women
  • preterm infants
  • autism spectrum disorder
  • gene expression
  • copy number