Effect of common genetic variants on the risk of cirrhosis in non-alcoholic fatty liver disease during 20 years of follow-up.

Magnus Holmer Mattias Ekstedt Patrik NasrRobin ZenlanderAxel WesterFederica TavaglioneStefano Romeo Stergios Kechagias Per Stål Hannes Hagström

Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)

The PNPLA3 G/G genotype is associated with an increased rate of cirrhosis in NAFLD. Our results suggest that assessment of the PNPLA3 genotype is of clinical relevance in patients with NAFLD to individualize monitoring and therapeutic strategies.

Keyphrases

liver fibrosis
clinical evaluation