Deoxycholic acid delays the wound healing of colonic epithelial cells via transmembrane G-protein-coupled receptor 5.
Yuka AzumaKazuhiko UchiyamaTakeshi SugayaTakeshi YasudaHikaru HashimotoMariko Kajiwara-KubotaSatoshi SuginoHiroaki KitaeTakashi ToriiKatsura MizushimaToshifumi DoiKen InoueOsamu DohiNaohisa YoshidaKazuhiro KamadaTakeshi IshikawaTomohisa TakagiHideyuki KonishiYuji NaitoYoshito ItohPublished in: Journal of gastroenterology and hepatology (2021)
Overall, we show that DCA delays wound healing in the context of colonic epithelial cells through AKT activation. These results may support the development of new therapeutic approaches for epithelial regeneration in UC.