HLA and Nasal Polyposis Susceptibility: A Meta-analysis of Worldwide Studies.

Ryan WitcherSugosh M AnurDylan ThibautLuciano VenturinoJordon G Grube

Published in: The Annals of otology, rhinology, and laryngology (2024)

This meta-analysis provides evidence that the HLA-DQA1*0201 and HLA-DRB1*7 alleles are risk factors for the development of NP. These findings could contribute to a better understanding of the genetic predisposition of NP and may have implications for the development of novel approaches for the prevention and treatment of this condition.

Keyphrases

systematic review
case control
chronic rhinosinusitis
gene expression
copy number
smoking cessation