Fourier Transform Infrared Spectroscopic, Spectrofluorimetric Assays of Canagliflozin, and Stability-Indicating UV-Spectrophotometric Method for the Simultaneous Determination of Canagliflozin and Metformin.
Sarah ElnadiSamah AbdalsabourMaha F Abd El GhanyYossra A TrabikPublished in: Journal of AOAC International (2022)
The proposed methods can be used efficiently for routine analysis in QC laboratories. A green FTIR method utilizes only one reagent, KBr. Spectrofluorimetry using a constant wavelength synchronous scan of CANA native fluorescence in nanogram concentrations overcomes conventional excitation/emission spectra drawbacks and proves that the solvent effect in the fluorescence intensity differs according to concentration used. Stability-indicating MCRS determines the studied drugs in bulk, pharmaceutical formulations, accelerated and long-term stability study samples.
Keyphrases
- simultaneous determination
- liquid chromatography tandem mass spectrometry
- energy transfer
- high performance liquid chromatography
- tandem mass spectrometry
- single molecule
- liquid chromatography
- solid phase extraction
- molecular docking
- high throughput
- magnetic resonance imaging
- ionic liquid
- mass spectrometry
- single cell
- gas chromatography