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Somatostatin Analogs for Pancreatic Neuroendocrine Tumors: Any Benefit When Ki-67 Is ≥10%?

Elettra MerolaTeresa Alonso GordoaPanpan ZhangTaymeyah Al-ToubahEleonora PellèAgnieszka Kolasińska-ĆwikłaWouter ZandeeFaidon LaskaratosLouis de MestierAngela LamarcaJorge HernandoJaroslaw CwiklaJonathan StrosbergWouter de HerderMartin CaplinMauro CivesRachel van Leeuwaarde
Published in: The oncologist (2020)
The results of the study call into question the antiproliferative activity of somatostatin analogs (SSAs) in pancreatic neuroendocrine tumors with Ki-67 ≥10%. Patients with grade 2 tumors and with hepatic tumor load ≤25% appear to derive higher benefit from SSAs. Prospective studies are needed to validate these results to optimize tailored therapeutic strategies for this specific patient population.
Keyphrases
  • neuroendocrine tumors
  • molecular docking
  • neoadjuvant chemotherapy
  • case report
  • smoking cessation