Deciphering spatially distinct immune microenvironments in glioblastoma using ferumoxytol and gadolinium-enhanced and FLAIR hyperintense MRI phenotypes.
Jared StollerCymon N KerschLeslie L MuldoonPrakash AmbadyChristina A HarringtonRongwei FuAhmed M RaslanAclan DoganEdward A NeuweltRamon Francisco BarajasPublished in: Neuro-oncology advances (2023)
Our study demonstrates the potential of Fe and Gd-enhanced MRI phenotypes to reveal spatially distinct immune processes within glioblastoma. Fe improves upon the standard of care Gd enhancement by specifically localizing glioblastoma-associated inflammatory processes, providing valuable insights into tumor biology.