Involvement of the IgE-basophil system and mild complement activation in haemophilia B with anti-factor IX neutralizing antibodies and anaphylaxis.
Massimo CugnoM E MancusoA TedeschiE SantagostinoM LoriniV CarbonelliFlora PeyvandiPier Mannuccio MannucciPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2017)
In the patient with haemophilia B who experienced anaphylaxis after FIX, but not in the patients with haemophilia B who tolerated FIX, the CAST assay showed FIX-induced LTC4 release, which was associated with high plasma levels of specific anti-FIX IgE and IgG antibodies.