Positive selection analyses identify a single WWE domain residue that shapes ZAP into a super restriction factor.
Serina HuangJuliana GirdnerLeAnn P NguyenDavid EnardMelody M H LiPublished in: bioRxiv : the preprint server for biology (2023)
genus. We observed that our mutant ZAP has reduced ability to bind poly(ADP-ribose), a post-translational modification that is targeted by alphaviruses for productive infection. Our findings help us better understand how viruses have shaped the evolution of broad-spectrum host antiviral proteins, with great implications for the engineering of super restriction factors.
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